The University of Michigan Pediatric Intensive Care Unit (PICU) at C.S. Mott Children's Hospital houses 30 beds for children with medical or surgical illnesses requiring the highest level of intensive monitoring or therapy. The PICU provides 24-hour care by a multidisciplinary care team of nurses, respiratory therapists, pharmacists, nutritionists -- all led by board-certified pediatric intensivists, critical care fellows, and pediatric residents. Our PICU enjoys an international reputation for excellence in the care of children with respiratory failure, especially those who require artificial organ support. The intensive care of asthma, increased intracranial pressure, respiratory failure, sepsis, multiple organ failure, nosocomial infections, bereavement, and teamwork are subjects of ongoing research. Nationally recognized programs in artificial organ support with extracorporeal membrane oxygenation (ECMO), hemodialysis and hemofiltration are unique to this critical care unit.